has material basis in germline mutation in PIK3CA hereditary disease CLAPO syndrome https://github.com/monarch-initiative/mondo/issues/4521 https://www.malacards.org/card/capillary_malformation_of_the_lower_lip_lymphatic_malformation_of_face_and_neck_asymmetry_of_face_and_limbs_and_partial_generalized_overgrowth capillary malformation of the LOWER LIP, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth Orphanet:168984 SCTID:717765001 CLAPO syndrome, somatic Lopez-Gutierrez syndrome MONDO:0013125 Clapo UMLS:C2751313 icd11.foundation:415642712 GARD:0017044 OMIM:613089 MEDGEN:416522 MESH:C567763 CLAPO syndrome is a newly described syndrome consisting of capillary malformation of the lower lip (C), lymphatic malformation of the face and neck (L), asymmetry of face and limbs (A) and partial or generalized overgrowth (O). overgrowth syndrome