has material basis in germline mutation in CHUK hereditary disease cocoon syndrome https://www.malacards.org/card/fetal_encasement_syndrome UMLS:C3150891 fetal encasement syndrome OMIM:613630 DOID:0060647 Fetal encasement syndrome is a rare, lethal developmental defect during embryogenesis characterized by severe fetal malformations, including craniofacial dysmorphism (abnormal cyst in the cranial region, hypoplastic eyeballs, two orifices in the nasal region separated by a nasal septum, abnormal orifice replacing the mouth), omphalocele and immotile, hypoplastic limbs encased under an abnormal, transparent, membrane-like skin. Additional features include absence of adnexal structures of the skin on the outer aspect of the limbs, as well as underdeveloped skeletal muscles and bones. Association with tetralogy of Fallot, horse-shoe kidneys and diaphragm and lung lobulation defects is reported. foetal encasement syndrome GARD:0017823 MONDO:0013334 Orphanet:465824 cocoon syndrome MEDGEN:462241 congenital limb malformation