has material basis in germline mutation in MED17 central nervous system disorder infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly https://www.malacards.org/card/microcephaly_postnatal_progressive_with_seizures_and_brain_atrophy OMIM:613668 MONDO:0013351 DOID:0111262 UMLS:C3150921 Orphanet:402364 MEDGEN:462271 Infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly is a rare, central nervous system malformation syndrome characterized by progressive microcephaly with profound motor delay and intellectual disability, associated with hypertonia, spasticity, clonus, and seizures, with brain imaging revealing severe cerebral and cerebellar atrophy, and poor myelination. postnatal progressive microcephaly, seizures, and brain atrophy GARD:0010995 hereditary neurological disease