has material basis in germline mutation in PSENEN acne inversa, familial, 2 https://www.malacards.org/card/acne_inversa_familial_2_with_or_without_dowling_degos_disease Any familial acne inversa in which the cause of the disease is a mutation in the PSENEN gene. MONDO:0013397 PSENEN familial acne inversa UMLS:C3151037 acne inversa, familial, type 2 familial acne inversa caused by mutation in PSENEN acne inversa, familial, 2 OMIM:613736 ACNINV2 MEDGEN:462387 familial acne inversa