has material basis in germline mutation in MASP2 immunodeficiency due to MASP-2 deficiency https://www.malacards.org/card/immunodeficiency_due_to_masp_2_deficiency https://www.malacards.org/card/masp2_deficiency MESH:C565360 UMLS:C3151085 Orphanet:331187 NANDO:2200793 OMIM:613791 immunodeficiency due to MASP-2 deficiency GARD:0017512 Immunodeficiency due to MASP-2 deficiency is a rare, genetic immunodeficiency due to a complement cascade protein anomaly characterized by low serum levels of MASP-2 and a variable susceptibility to bacterial infections (e.g. pulmonary tuberculosis, pneumococcal pneumonia, skin abscesses and sepsis), and autoimmune diseases (e.g. inflammatory lung disease, cystic fibrosis, systemic lupus erythematosus). In many cases it remains asymptomatic. MEDGEN:462435 MONDO:0013423 disorder of lectin complement activation pathway