has material basis in germline mutation in HMOX1 heme oxygenase 1 deficiency https://github.com/monarch-initiative/mondo/issues/4521 https://www.malacards.org/card/heme_oxygenase_1_deficiency_2 MEDGEN:333882 HMOX1D MESH:C564200 MONDO:0013536 heme oxygenase-1 deficiency heme oxygenase 1 deficiency UMLS:C1841651 GARD:0017995 Orphanet:562509 OMIM:614034 inborn disorder of porphyrin metabolism