has material basis in germline mutation in disease has feature WFS1 type 1 diabetes mellitus endocrine system disorder Wolfram-like syndrome https://www.malacards.org/card/autosomal_dominant_wolfram_syndrome https://www.malacards.org/card/wolfram_like_syndrome https://www.malacards.org/card/wolfram_like_syndrome_autosomal_dominant OMIM:614296 Wolfram-like syndrome hearing loss, progressive, with optic atrophy and/or impaired glucose Regulation UMLS:C3280358 Wolfram-like syndrome is a rare endocrine disease characterized by the triad of adult-onset diabetes mellitus, progressive hearing loss (usually presenting in the first decade of life and principally of low to moderate frequencies), and/or juvenile-onset optic atrophy. Psychiatric (i.e. anxiety, depression, hallucinations) and sleep disorders, the only neurologic abnormalities observed in this disease, have been reported in rare cases. Unlike Wolfram syndrome, patients with Wolfram-like syndrome do not report endocrine or cardiac findings. MEDGEN:481988 Orphanet:411590 MESH:C565631 WFSL Wolfram-like syndrome, autosomal dominant GARD:0017683 DOID:0080584 SCTID:734022008 MONDO:0013673 WFS1-related disorder