has characteristic has characteristic has material basis in germline mutation in PMS2 Autosomal dominant inheritance Lynch syndrome Lynch syndrome 4 https://github.com/monarch-initiative/mondo/issues/5666 https://github.com/monarch-initiative/mondo/issues/9178 https://www.malacards.org/card/lynch_syndrome_4 MONDO:0013699 UMLS:C1838333 PMS2-related Lynch syndrome HNPCC4 MESH:C563971 PMS2 hereditary nonpolyposis colon cancer MEDGEN:325005 colorectal cancer, hereditary nonpolyposis, type 4 DOID:0070275 An autosomal dominant hereditary neoplastic caused by pathogenic variants in the PMS2 mismatch repair gene. It is characterized by an increased risk of colorectal cancer in the absence of extensive polyposis, endometrial, ovarian, gastric, small intestinal, and urinary tract cancers. GARD:0015791 hereditary nonpolyposis colon cancer caused by mutation in PMS2 OMIM:614337 hereditary nonpolyposis colon cancer