has characteristic has characteristic has material basis in germline mutation in MSH6 Autosomal dominant inheritance Lynch syndrome Lynch syndrome 5 https://github.com/monarch-initiative/mondo/issues/5666 https://github.com/monarch-initiative/mondo/issues/9178 https://www.malacards.org/card/lynch_syndrome_5 UMLS:C1833477 hereditary nonpolyposis colon cancer caused by mutation in MSH6 GARD:0015792 HNPCC5 MONDO:0013710 MSH6 hereditary nonpolyposis colon cancer OMIM:614350 An autosomal dominant hereditary neoplastic syndrome caused by pathogenic variants in the MSH6 mismatch repair gene. It is characterized by an increased risk of colorectal cancer in the absence of extensive polyposis, endometrial, ovarian, gastric, small intestinal, and urinary tract cancers, often occuring at younger ages. MESH:C563456 MEDGEN:318886 DOID:0070272 colorectal cancer, hereditary nonpolyposis, type 5 MSH6-related Lynch Syndrome hereditary nonpolyposis colon cancer