has material basis in germline mutation in STK4 combined immunodeficiency due to STK4 deficiency https://github.com/monarch-initiative/mondo/issues/4521 https://www.malacards.org/card/immunodeficiency_110_with_lymphoproliferation Orphanet:314689 T-cell immunodeficiency, recurrent infections, and autoimmunity with or without CARDIAC malformations TIIAC GARD:0017430 UMLS:C3553943 MONDO:0013934 CID due to STK4 deficiency MST1 deficiency OMIM:614868 A rare, genetic combined T and B cell immunodeficiency characterized by T- and B-cell lymphopenia, hypergammaglobulinemia and intermittent neutropenia. It presents with recurrent opportunistic viral, bacterial and fungal infections involving skin (cutaneous papillomatosis, molluscum contagiosum, skin abscesses, mucocutaneous candidiasis), upper and lower respiratory tract or septicemia. Other clinical features include autoimmune manifestations (autoimmune hemolytic anemia) and congenital heart defects (atrial septal defects, patent foramen ovale, mitral, triscupid and pulmonary valve insufficiency). MEDGEN:766857 STK4 deficiency T-cell immunodeficiency, recurrent infections, autoimmunity, and cardiac malformations combined immunodeficiency non-SCID combined immunodeficiency