has material basis in germline mutation in disease has feature CACNA1D sinoatrial node disorder cardiac rhythm disease sinoatrial node dysfunction and deafness https://www.malacards.org/card/sinoatrial_node_dysfunction_and_deafness Orphanet:324321 sinoatrial node dysfunction and deafness UMLS:C3554018 OMIM:614896 MONDO:0013960 SANDD MEDGEN:766932 Sinoatrial node dysfunction and deafness is a rare genetic disease characterized by congenital severe to profound deafness with no evidence of vestibular dysfunction, associated with sinoatrial node dysfunction with pronounced bradycardia and increased variability of heart rate at rest and episodic syncopes that may be triggered by enhanced physical activity and stress. GARD:0017484 cardiogenetic disease