has material basis in germline mutation in ASXL3 syndromic intellectual disability hereditary disease Bainbridge-Ropers syndrome https://github.com/monarch-initiative/mondo/issues/10783 https://github.com/monarch-initiative/mondo/issues/5588 https://www.malacards.org/card/bainbridge_ropers_syndrome Bainbridge-Ropers syndrome BRPS MEDGEN:1656239 OMIM:615485 ASXL3-Related Disorder Any multiple congenital anomalies/dysmorphic syndrome-intellectual disability in which the cause of the disease is a variation in the ASXL3 gene. It is characterized by microcephaly, severe feeding difficulties, failure to thrive, severe global developmental delay that frequently results in absent or poor speech, moderate to severe intellectual disability and hypotonia. Distinctive craniofacial features include prominent forehead, high-arched, thin eyebrows, hypertelorism, downslanting palpebral fissures, long, tubular nose with broad tip and prominent nasal bridge and wide mouth with full, everted lower lip. Joint laxity and ulnar deviation of wrists are also frequently observed. severe feeding difficulties-failure to thrive-microcephaly due to ASXL3 deficiency syndrome GARD:0013259 MONDO:0014205 Orphanet:352577 NORD:139551 DOID:0080893 UMLS:C4750837 multiple congenital anomalies/dysmorphic syndrome-intellectual disability