has material basis in germline mutation in UCHL1 early-onset progressive neurodegeneration-blindness-ataxia-spasticity syndrome https://www.malacards.org/card/spastic_paraplegia_79b_autosomal_recessive MONDO:0014209 DOID:0112344 Orphanet:352654 SPG79 MEDGEN:815995 neurodegeneration with optic atrophy, childhood-onset Early-onset progressive neurodegeneration-blindness-ataxia-spasticity syndrome is a genetic neurodegenerative disease characterized by normal early development followed by childhood onset optic atrophy with progressive vision loss and eventually blindness, followed by progressive neurological decline that typically includes cerebellar ataxia, nystagmus, dorsal column dysfunction (decreased vibration and position sense), spastic paraplegia and finally tetraparesis. OMIM:615491 UMLS:C3809665 GARD:0017523 NDGOA hereditary spastic paraplegia