has material basis in germline mutation in DSG1 syndromic disease hereditary disease skin disorder allergic disease severe dermatitis-multiple allergies-metabolic wasting syndrome https://github.com/monarch-initiative/mondo/issues/4521 https://github.com/monarch-initiative/mondo/issues/5682 https://github.com/monarch-initiative/mondo/issues/5914 https://www.malacards.org/card/erythroderma_congenital_with_palmoplantar_keratoderma_hypotrichosis_and_hyper_ige_2 UMLS:C3809719 EPKHE congenital erythroderma-hypotrichosis-recurrent infections-multiple food allergies syndrome erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper-IgE MEDGEN:816049 GARD:0017594 Orphanet:369992 SAM syndrome MONDO:0014218 erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper IgE OMIM:615508 hyper-IgE syndrome epidermal disease