has material basis in germline mutation in TPI1 glucose metabolism disease familial hemolytic anemia triosephosphate isomerase deficiency https://github.com/monarch-initiative/mondo/issues/4521 https://github.com/monarch-initiative/mondo/issues/4985 https://rarediseases.info.nih.gov/diseases/5287/triosephosphate-isomerase-deficiency https://www.malacards.org/card/triosephosphate_isomerase_deficiency MONDO:0014221 hemolytic anemia due to triosephosphate isomerase deficiency Triosephosphate isomerase (TPI) deficiency is a severe autosomal recessive inherited multisystem disorder of glycolytic metabolism characterized by hemolytic anemia and neurodegeneration. OMIM:615512 MEDGEN:349893 DOID:0050884 MESH:C566029 SCTID:234405009 Orphanet:868 NCIT:C131652 NORD:1793 triose phosphate-isomerase deficiency UMLS:C1860808 TPI deficiency GARD:0005287 TPID triosephosphate isomerase deficiency ICD9:282.3 hemolytic anaemia due to triosephosphate isomerase deficiency disorder of glycolysis anemia due to erythrocyte enzyme disorder