has material basis in germline mutation in UNC119 idiopathic CD4 lymphocytopenia https://www.malacards.org/card/immunodeficiency_13 MONDO:0014226 OMIM:615518 UMLS:C3809768 A rare primary immunodeficiency disorder characterized by persistent CD4 T-cell lymphopenia (less than 300 cells/B5L on multiple occasions) not associated with any other underlying primary or secondary immune deficiency. Patients typically present opportunistic infections (with cryptococcal, mycobacterial, candidal, varicella zoster virus infections and progressive multifocal leukoencephalopathy being the most prevalent), malignancies (mainly lymphoproliferative disorders), or autoimmune disorders. Some individuals are asymptomatic and incidentally diagnosed. SCTID:763713000 immunodeficiency type 13 Orphanet:228000 DOID:0111987 IMD13 icd11.foundation:1639000446 ICL GARD:0012375 MEDGEN:816098 immunodeficiency 13 idiopathic CD4 positive T-lymphocytopenia idiopathic Cd4 lymphopenia non-SCID combined immunodeficiency immunodeficiency disease idiopathic disease