has characteristic has characteristic has material basis in germline mutation in PRLR hyperprolactinemia familial hyperprolactinemia https://www.malacards.org/card/familial_hyperprolactinemia https://www.malacards.org/card/hyperprolactinemia UMLS:C4706551 hyperprolactinemia GARD:0017634 OMIM:615555 MEDGEN:1645317 hereditary hyperprolactinemia (disease) SCTID:763715007 Orphanet:397685 HPRL familial isolated prolactin receptor deficiency MONDO:0014250 Familial hyperprolactinemia is a rare, genetic endocrine disorder characterized by persistently high prolactin serum levels (not associated with gestation, puerperium, drug intake or pituitary tumor) in multiple affected family members. Clinically it manifests with signs usually observed in hyperprolactinemia, which are: secondary medroxyprogesterone acetate (MPA)-negative amenorrhea and galactorrhea in female patients, and hypogonadism and decreased testosterone level-driven sexual disfunction in male patients. Oligomenorrhea and primary infertility have also been reported in some female patients. familial hyperprolactinemia inherited hereditary neurological disease