obsolete autoimmune lymphoproliferative syndrome type 3 https://github.com/monarch-initiative/mondo/issues/4098 true ALPS-U autoimmune lymphoproliferative syndrome-undetermined variant This will be obsoleted in the 2022-04-01 release. The term will be split and the new IDs for this term will be MONDO:800023 (Type 3 Autoimmune Lymphoproliferative Syndrome) and MONDO:800024 (autoimmune lymphoproliferative syndrome, type III caused by mutation in PRKCD). MONDO:0014253 autoimmune lymphoproliferative syndrome caused by mutation in PRKCD CVID9 autoimmune lymphoproliferative syndrome type III autoimmune lymphoproliferative syndrome, type III ALPS3 OBSOLETE. A rare, primary immunodeficiency. It is caused by a currently undetermined defect in the Fas-induced apoptosis pathway. No mutations in Fas, FASLG or CASP10 are detectable. Disruption of Fas-induced apoptosis impairs lymphocyte homeostasis and immune tolerance. Characteristic laboratory findings include an increase in circulating, double-negative (CD4-/CD8-) T cells in the setting of immune-mediated anemia, thrombocytopenia and neutropenia. Clinical signs present in childhood include fatigue, pallor, bruising, hepatosplenomegaly and chronic, non-malignant, non-infectious lymphadenopathy. The clinical course is influenced by a strong association with other autoimmune disorders and an increased risk for developing Hodgkin and non-Hodgkin lymphoma. NANDO:2200743 type 3 ALPS common variable immunodeficiency 9 PRKCD autoimmune lymphoproliferative syndrome type 3 autoimmune lymphoproliferative syndrome autoimmune lymphoproliferative syndrome, type III caused by mutation in PRKCD term split