has material basis in germline mutation in CD3E immunodeficiency 18 https://www.malacards.org/card/immunodeficiency_18 Immunodeficiency-18 is an autosomal recessive primary immunodeficiency characterized by onset in infancy or early childhood of recurrent infections. Immunologic work-up of the IMD18 SCID patients shows a T cell-negative, B cell-positive, natural killer (NK) cell-positive phenotype, whereas T-cell development is not impaired in the mild form of IMD18. IMD18 DOID:0060017 UMLS:C3810127 CD3-Epsilon deficiency immunodeficiency 18 MONDO:0014278 immunodeficiency 18, SCID variant MEDGEN:816457 OMIM:615615 immunodeficiency type 18 immunodeficiency 18, Severe combined immunodeficiency variant DOID:0111971 GARD:0018295 T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta familial severe combined immunodeficiency