has material basis in germline mutation in ADA2 deficiency of adenosine deaminase 2 https://github.com/monarch-initiative/mondo/issues/4521 https://github.com/monarch-initiative/mondo/issues/6166 https://github.com/monarch-initiative/mondo/issues/6748 https://github.com/monarch-initiative/mondo/issues/6878 https://github.com/monarch-initiative/mondo/issues/7365 https://github.com/monarch-initiative/mondo/issues/9413 https://www.malacards.org/card/vasculitis_autoinflammation_immunodeficiency_and_hematologic_defects_syndrome OMIM:615688 NANDO:1200995 PAN ADA2 deficiency NANDO:2200441 deficiency of adenosine deaminase 2 vasculitis, autoinflammation, immunodeficiency, and hematologic defects syndrome MONDO:0014306 UMLS:C3887654 Orphanet:404553 adenosine deaminase 2 deficiency NANDO:2200450 MEDGEN:854497 DADA2 childhood-onset polyarteritis nodosa polyarteritis nodosa, childhood-onset GARD:0012383 A rare autoinflammatory disease characterized by a broad clinical phenotype of systemic inflammation, vasculitis, early-onset stroke, immunodeficiency and bone marrow failure. The disease typically presents in young children, although adult cases are being discovered. vasculitis hereditary disorder of connective tissue type 1 interferonopathy of childhood