has material basis in germline mutation in ZP1 female infertility due to zona pellucida defect https://www.malacards.org/card/female_infertility_due_to_zona_pellucida_defect https://www.malacards.org/card/oocyte_zygote_embryo_maturation_arrest_1 Orphanet:404466 oocyte maturation defect Female infertility due to zona pellucida defect is a rare, genetic, female infertility disorder characterized by the presence of abnormal oocytes that lack a zona pellucida. Affected individuals are unable to conceive despite having normal menstrual cycles and sex hormone levels, as well as no obstructions in the fallopian tubes or defects of the uterus or adnexa. MONDO:0014342 OOMD MEDGEN:862728 OMIM:615774 OOMD1 oocyte maturation defect 1 GARD:0017675 UMLS:C4014291 inherited oocyte maturation defect female infertility