orofacial cleft familial median cleft of the upper and lower lips https://github.com/monarch-initiative/mondo/issues/6876 https://www.malacards.org/card/familial_median_cleft_of_the_upper_and_lower_lips https://www.malacards.org/card/orofacial_cleft_14 MONDO:0014388 orofacial cleft 14 Familial median cleft of the upper and lower lips is a rare and isolated orofacial defect characterized by incomplete median clefts of both the lower lip (limited to the vermilion, with no muscle involvement) and upper lip (with muscle involvement), double labial frenulum and fusion of the upper gingival and upper labial mucosa (resulting in a shallow upper vestibular fold), in addition to poor dental alignment, and increased interdental distance between the lower and upper median incisors. Variable expressivity has been reported in an affected family. Orphanet:401942 DOID:0080407 OFC14 GARD:0017663 UMLS:C4014596 MEDGEN:863033 OMIM:615892 disorder of development or morphogenesis