has material basis in germline mutation in ARNT2 hereditary disease Webb-Dattani syndrome https://www.malacards.org/card/webb_dattani_syndrome hypothalamic insufficiency-secondary microcephaly-visual impairment-urinary anomalies syndrome WEBB-Dattani syndrome MEDGEN:863145 Orphanet:370006 WEDAS UMLS:C4014708 Webb-Dattani syndrome hypothalamo-pituitary-frontotemporal hypoplasia with visual and renal anomalies MONDO:0014404 OMIM:615926