has material basis in germline mutation in IGFALS hereditary disease short stature due to primary acid-labile subunit deficiency https://github.com/monarch-initiative/mondo/issues/4521 https://www.malacards.org/card/acid_labile_subunit_deficiency MONDO:0014420 Short stature due to primary acid-labile subunit (ALS) deficiency is characterized by moderate postnatal growth deficit, markedly low circulating levels of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP-3), and hyperinsulinemia, in the absence of growth hormone (GH) deficiency or GH insensitivity. GARD:0016964 MEDGEN:859716 Orphanet:140941 acid-labile SUBUNIT deficiency UMLS:C3900122 acid-labile subunit, deficiency of icd11.foundation:29735645 SCTID:721074002 OMIM:615961 ACLSD growth hormone insensitivity syndrome