has material basis in germline mutation in GRHL2 nail and teeth abnormalities-marginal palmoplantar keratoderma-oral hyperpigmentation syndrome https://www.malacards.org/card/ectodermal_dysplasia_short_stature_syndrome ECTDS short stature-nail dysplasia-marginal palmoplantar keratoderma-oral hyperpigmentation syndrome MEDGEN:863424 ectodermal dysplasia-short stature syndrome OMIM:616029 Orphanet:423454 ectodermal dysplasia/short stature syndrome UMLS:C4014987 Nail and teeth abnormalities-marginal palmoplantar keratoderma-oral hyperpigmentation syndrome is a rare genetic ectodermal dysplasia syndrome characterized by short stature, nail dystrophy and/or nail loss, oral mucosa and/or tongue hyperpigmentation, dentition abnormalities (delayed teeth eruption, hypodontia, enamel hypoplasia), keratoderma on the margins of the palms and soles and focal hyperkeratosis on the dorsum of the hands and feet. Additionally, dysphagia with esophageal strictures, sensorineural deafness, bronchial asthma and severe iron-deficiency anemia have been observed. MONDO:0014460 GARD:0017703 focal palmoplantar keratoderma ectodermal dysplasia syndrome hyperpigmentation of the skin