has material basis in germline mutation in KANK2 wooly hair-palmoplantar keratoderma syndrome https://www.malacards.org/card/palmoplantar_keratoderma_and_woolly_hair palmoplantar keratoderma and woolly hair Woolly hair-palmoplantar keratoderma syndrome is a very rare, hereditary epidermal disorder characterized by hypotrichosis/wooly scalp hair, sparse body hair, eyelashes and eyebrows, leukonychia, and striate palmoplantar keratoderma (more severe on the soles than the palms), which progressively worsens with age. Pseudo ainhum of the fifth toes was also reported. Although wooly hair-palmoplantar keratoderma syndrome shares clinical similarities with both Naxos disease and Carvajal syndrome, cardiomyopathy is notably absent. PPKWH OMIM:616099 SCTID:764108000 Orphanet:420686 UMLS:C4015202 woolly hair-palmoplantar hyperkeratosis syndrome GARD:0017697 MONDO:0014492 KWWH type IV palmoplantar keratoderma and wooly hair keratoderma with woolly hair type IV wooly hair-palmoplantar hyperkeratosis syndrome keratoderma with wooly hair type IV MEDGEN:863639 DOID:0070554 focal palmoplantar keratoderma