has material basis in germline mutation in ISG15 Mendelian susceptibility to mycobacterial diseases due to complete ISG15 deficiency https://github.com/monarch-initiative/mondo/issues/4521 https://www.malacards.org/card/immunodeficiency_38_with_basal_ganglia_calcification autosomal recessive mendelian susceptibility to mycobacterial diseases due to a complete deficiency caused by mutation in ISG15 UMLS:C4015293 Orphanet:319563 GARD:0017458 ISG15 autosomal recessive mendelian susceptibility to mycobacterial diseases due to a complete deficiency MONDO:0014502 MSMD due to complete ISG15 deficiency immunodeficiency 38 with basal ganglia calcification Editor note: In ORDO classified at type 1 interferonopathy but we exclude this, as it is an autoinflammatory disease DOID:0111934 MEDGEN:863730 OMIM:616126 IMD38 Mendelian susceptibility to mycobacterial diseases (MSMD) due to complete ISG15 deficiency is a genetic variant of MSMD characterized by Bacille Calmette-GuC)rin (BCG) infections. obsolete type 1 interferonopathy inherited susceptibility to mycobacterial diseases