has material basis in germline mutation in KDM1A syndromic intellectual disability hereditary disease palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome https://github.com/monarch-initiative/mondo/issues/5588 https://www.malacards.org/card/cleft_palate_psychomotor_retardation_and_distinctive_facial_features https://www.malacards.org/card/palatal_anomalies_widely_spaced_teeth_facial_dysmorphism_developmental_delay_syndrome UMLS:C4225229 Orphanet:477993 Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome is a rare, genetic multiple congenital anomalies/dysmorphic syndrome characterized by global developmental delay, axial hypotonia, palate abnormalities (including cleft palate and/or high and narrow palate), dysmorphic facial features (including prominent forehead, hypertelorism, downslanting palpebral fissures, wide nasal bridge, thin lips and widely spaced teeth), and short stature. Additional manifestations may include digital anomalies (such as brachydactyly, clinodactyly, and hypoplastic toenails), a single palmar crease, lower limb hypertonia, joint hypermobility, as well as ocular and urogenital anomalies. MEDGEN:895943 GARD:0017862 palatal anomalies-multiple diastemata-facial dysmorphism-developmental delay syndrome OMIM:616728 CPRF MONDO:0014751 multiple congenital anomalies/dysmorphic syndrome-intellectual disability