arrhinia https://rarediseases.info.nih.gov/diseases/364/arrhinia https://www.malacards.org/card/isolated_arrhinia MESH:C537438 GARD:0000364 Nose agenesis MEDGEN:120555 congenital absence of the nose SCTID:111317000 Arrhinia is an extremely rare, major congenital malformation consisting of an absence of the nose ranging from hyporrhinia (absence of external nasal structures) to total arrhinia (absence of external nose, nasal airways, olfactory bulbs, or olfactory nerve) often causing respiratory distress and requiring surgical correction. Arrhinia can be bilateral or unilateral (hemiarrhinia). Associated anomalies include ocular features (hypertelorism, microphthalmia, eyelid coloboma), facial clefts, midline defects and microtia. Nose agenesia isolated arrhinia MONDO:0015237 icd11.foundation:409489963 isolated nose agenesis UMLS:C0265740 Orphanet:1134 ICD9:748.1 otorhinolaryngologic disease