melanocytic nevus segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome https://github.com/monarch-initiative/mondo/issues/6877 https://www.malacards.org/card/segmental_outgrowth_lipomatosis_arteriovenous_malformation_epidermal_nevus_syndrome MONDO:0015293 MEDGEN:1637405 GARD:0019881 Orphanet:137608 UMLS:C4706610 SOLAMEN syndrome Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome is a rare, genetic, polymalformative syndrome characterized by progressive, proportionate, asymmetric segmental overgrowth (with soft tissue hypertrophy and ballooning effect) that develops and progresses rapidly in early childhood, arteriovenous and lymphatic vascular malformations, lipomatosis and linear epidermal nevus (arranged in whorls along the lines of Blaschko). Clinical symptoms of Cowden syndrome, such as macrocephaly and progressive development of numerous hypertrophic hamartomatous and neoplastic lesions involving multiple organs and systems, are also associated. Patients present an increased risk of developing cancer. SCTID:763867001 PTEN hamartoma tumor syndrome overgrowth syndrome hereditary skin disorder