progressive cavitating leukoencephalopathy https://www.malacards.org/card/progressive_cavitating_leukoencephalopathy MONDO:0015349 SCTID:719267003 GARD:0019918 MEDGEN:930509 UMLS:C4304840 icd11.foundation:340540374 Orphanet:139447 Progressive cavitating leukoencephalopathy is characterized by acute episodes of neurological deficit (ataxia, dysarthria, seizures) with irritability and opisthotonus followed by either steady deterioration or alternating periods of rapid progression and prolonged periods of stability. leukodystrophy