autoimmune disease of ear, nose and throat eye disorder Cogan syndrome https://www.malacards.org/card/cogan_syndrome icd11.foundation:2098089327 MedDRA:10056667 Cogan syndrome (CS) is a rare autoimmune disorder of unknown origin characterized by inflammatory ocular disease (mainly interstitial keratitis) and vestibulo-auditory manifestations (mainly acute onset hearing loss, tinnitus and vertigo), in the setting of a negative work-up for syphilis, with a variable risk of developing into a systemic disease. Systemic manifestations may occur in more than 70% of cases. MONDO:0015453 DOID:0060216 Orphanet:1467 MESH:D055952 SCTID:405810005 UMLS:C0271270 Cogan syndrome GARD:0001421 MEDGEN:82871