macroglossia MONDO:0015496 giant tongue enlarged tongue MEDGEN:44236 The presence of an excessively large tongue, which may be congenital or may develop as a result of a tumor or edema due to obstruction of lymphatic vessels, or it may occur in association with hyperpituitarism or acromegaly. It also may be associated with malocclusion because of pressure of the tongue on the teeth. (From Jablonski, Dictionary of Dentistry, 1992) Orphanet:156207 MedDRA:10025391 UMLS:C0024421 icd11.foundation:670519908 GARD:0003342 MESH:D008260 developmental defect during embryogenesis disorder of facial skeleton