non-Langerhans cell histiocytosis progressive nodular histiocytosis https://www.malacards.org/card/progressive_nodular_histiocytosis SCTID:765141005 MONDO:0015539 MEDGEN:1647278 Orphanet:158022 Progressive nodular histiocytosis is a rare, normolipemic, non-Langerhans cell histiocytosis characterized by progressive growth of multiple to disseminated, asymptomatic skin lesions that range in appearance from yellow plaques to coalescence-prone red-brown papules, nodules and pedunculated tumors up to 5 cm in size, located typically on the face, trunk and extremities (and rarely on conjuctiva and mucous membranes). Characteristic microscopic findings include a storiform spindle cell infiltrate in the deep dermis with xanthomatized macrophages and some Touton cells in the upper dermis. It is usually not associated with systemic disease. icd11.foundation:1576286064 GARD:0020023 UMLS:C4707331