limbic encephalitis with LGI1 antibodies limbic encephalitis with leucine-rich glioma-inactivated 1 antibodies Orphanet:163908 MEDGEN:1645969 UMLS:C4706583 GARD:0013406 Limbic encephalitis with LGI1 antibodies is a rare neuroimmunological disorder characterized by the onset of cognitive decline, psychiatric disturbances and seizures (distinctively faciobrachial dystonic seizures) in association with detection of LGI1 antibodies in serum or cerebrospinal fluid. Patients may present with confusion, hallucinations, vocalization, paranoia, tangentiality, aggressive outbursts and/or spatial disorientation, as well as obstinate hyponatremia. It is most often non-paraneoplastic, however comorbid tumors, such as small cell lung cancer and thymoma, have been reported. SCTID:763794005 MONDO:0015592 postinfectious encephalitis