von Willebrand disease 2 von Willebrand disease type 2B von Willebrand disease type 2B A subtype of type 2 VWD characterized by a bleeding disorder associated with an increase in the affinity of the Willebrand factor (von Willebrand factor; VWF) for platelets. This anomaly results in spontaneous binding of high molecular weight VWF multimers to platelets leading to rapid clearance of both the platelets (increasing the risk of thrombocytopenia) and the high molecular weight VWF multimers from the plasma. von Willebrand disease, type 2B icd11.foundation:1383884415 GARD:0017022 NCIT:C131687 MONDO:0015629 SCTID:359721009 Orphanet:166087 UMLS:C1282971 MEDGEN:224831 SCTID:359717002