myeloid/lymphoid neoplasms associated with eosinophilia and abnormality of PDGFRA, PDGFRB, FGFR1 or JAK2 myeloid neoplasm associated with PDGFRA rearrangement https://github.com/monarch-initiative/mondo/issues/3845 https://www.malacards.org/card/myeloid_and_lymphoid_neoplasms_associated_with_pdgfra_rearrangement MONDO:0015689 DOID:0080165 ONCOTREE:MLNPDGFRA UMLS:C4545381 NCIT:C84275 GARD:0020106 myeloid and lymphoid neoplasms associated with PDGFRA rearrangement myeloid/lymphoid neoplasms with PDGFRA rearrangement SCTID:738527001 myeloid and lymphoid neoplasms with PDGFRA rearrangement Orphanet:168947 ICDO:9965/3 A rare, malignant, neoplastic disease characterized by clonal proliferation of myeloid and/or lymphoid precursors harboring rearrangements in the PDGFRA gene, in the blood, bone marrow and often other tissues as well (spleen, lymph nodes, skin, etc.). It usually presents as chronic eosinophilic leukemia or, less commonly, as acute myeloid leukemia or T-lymphoblastic leukemia with eosinophilia. Patients usually present with eosinophilia, anemia, thrombocytopenia, neutrophilia, splenomegaly, lymphadenopathy, fever, sweating and/or weight loss. Tissue infiltration by eosinophils can manifest with skin rash, erythema, cough, neurological alterations, gastrointestinal symptoms or, rarely, endomyocardial fibrosis and restrictive cardiomyopathy. MEDGEN:1620600 icd11.foundation:833355630