disease has basis in disruption of disease caused by disruption of calcium channel activity combined immunodeficiency combined immunodeficiency due to CRAC channel dysfunction https://github.com/monarch-initiative/mondo/issues/6747 https://github.com/monarch-initiative/mondo/issues/6877 https://www.malacards.org/card/combined_immunodeficiency_due_to_crac_channel_dysfunction A form of combined immunodeficiency characterized by recurrent infections, autoimmunity, congenital myopathy and ectodermal dysplasia. It comprises two sub-types that are due to mutations in the ORAI1 and STIM1 genes: CID due to ORAI1 deficiency and CID due to STIM1 deficiency. MONDO:0015695 icd11.foundation:1641826886 MEDGEN:929240 immune dysfunction due to T-cell inactivation due to calcium entry defect GARD:0017048 SCTID:717811007 UMLS:C4303571 Orphanet:169090