disease arises from feature disease has basis in feature Globozoospermia male infertility male infertility due to globozoospermia https://github.com/monarch-initiative/mondo/issues/9812 https://www.malacards.org/card/male_infertility_due_to_globozoospermia A male infertility due to sperm disorder characterized by the presence, in sperm, of a large majority of round-headed spermatozoa that lack the acrosome and have an aberrant nuclear membrane and midpiece defects. The acrosomeless spermatozoa is not able to penetrate the zona pellucida following intercourse or IVF thus fertilization fails. Fertilization efficiency is also very low following intracytoplasmic spem injection due to the absence of the oocyte activation factor protein PLCzeta. MONDO:0015746 UMLS:C5679591 round-headed sperm syndrome MEDGEN:1826006 Male infertility due to round-headed spermatozoa DOID:0112312 male infertility due to globozoospermia male infertility due to round-headed spermatozoa Orphanet:171709 GARD:0012502 male infertility with teratozoospermia due to single gene mutation