syndromic disease fetal hydantoin syndrome https://github.com/monarch-initiative/mondo/issues/5507 https://github.com/monarch-initiative/mondo/issues/6876 https://rarediseases.info.nih.gov/diseases/6435/fetal-hydantoin-syndrome https://www.malacards.org/card/fetal_hydantoin_syndrome NCIT:C98927 ICD10CM:Q86.1 icd11.foundation:1894344911 UMLS:C0265372 Orphanet:1912 fetal dihydantoin syndrome MEDGEN:75569 phenytoin embryofetopathy NORD:1139 phenytoin embryopathy Dilantin embryopathy Fetal hydantoin syndrome is a drug-related embryofetopathy that can occur when an embryo/fetus is exposed to the anticonvulsant drug phenytoin, characterized by distinct craniofacial anomalies (hypertelorism and epicanthal folds, short nose and deep nasal bridge, malformed and low set ears, short neck) as well as hypoplastic distal phalanges and underdevelopment of nails of fingers and toes, prenatal and postnatal growth retardation, and neurological impairment (at a 2-3 times higher risk than that of the general population) including cognitive deficits and motor developmental delay. Less commonly, microcephaly, ocular defects, oral clefts, umbilical and inguinal hernias, hypospadias and cardiac anomalies have also been reported. ICD9:759.89 MESH:C537922 foetal dihydantoin syndrome MONDO:0016008 SCTID:70065001 MedDRA:10016508 FHS toxic or drug-related embryofetopathy