late-onset isolated ACTH deficiency https://www.malacards.org/card/late_onset_isolated_acth_deficiency Orphanet:199299 GARD:0020331 icd11.foundation:1651831896 Late-onset isolated ACTH deficiency is a rare, acquired, pituitary hormone deficiency characterized by secondary adrenal insufficiency, with normal secretion of anterior pituitary hormones, except for ACTH. Patients present with weakness, fatigue, weight loss, anorexia, vomiting/nausea, hypoglycemia, and abnormally low serum ACTH and cortisol levels. Association with autoimmune disease such as Hashimoto's thyroiditis has been described. MONDO:0016042 UMLS:C4751433 MEDGEN:1651973 acquired pituitary hormone deficiency