dermis tumor soft tissue neoplasm hyaline fibromatosis syndrome juvenile hyaline fibromatosis Puretic syndrome MONDO:0016071 GARD:0016583 ICD9:733.29 Orphanet:2028 Molluscum fibrosum Juvenile hyaline fibromatosis (JHF) is a rare soft tissue tumor, characterized by papulo-nodular skin lesions (especially around the head and neck), soft tissue masses, gingival hypertrophy, joint contractures, and osteolytic bone lesions in variable degrees. Joint contractures may cripple patients and delay normal motor development if occurring in infancy. Severe gingival hyperplasia can interfere with eating and delay dentition. Histopathology analysis of involved tissues reveals cords of spindle-shaped cells embedded in an amorphous, hyaline material. JHF is a mild form of infantile systemic hyalinosis. MEDGEN:411197 SCTID:238861002 mesenchymal dysplasia icd11.foundation:1890146024 UMLS:C2745948 Murray-Puretic-Drescher syndrome NCIT:C98297 bone neoplasm hereditary disorder of connective tissue hereditary skin disorder