syndromic intellectual disability syndromic disease congenital nervous system disorder multiple congenital anomalies/dysmorphic syndrome-intellectual disability holoprosencephaly https://github.com/monarch-initiative/mondo/issues/5588 https://rarediseases.info.nih.gov/diseases/6665/holoprosencephaly https://www.malacards.org/card/holoprosencephaly MONDO:0016296 MEDGEN:38214 holoprosencephaly sequence NCIT:C74988 NORD:1247 UMLS:C0079541 Orphanet:2162 OMIMPS:236100 GARD:0006665 ICD10CM:Q04.2 Holoprosencephaly (HPE) is a complex brain malformation resulting from incomplete cleavage of the prosencephalon, occurring between the 18th and 28th day of gestation, and affecting both the forebrain and face, which results in neurological manifestations and facial anomalies of variable severity. SCTID:30915001 NANDO:2200819 MESH:D016142 HPE DOID:4621 MedDRA:10056304 icd11.foundation:1712699129 non-acquired combined pituitary hormone deficiency hereditary neurological disease