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    <!-- http://purl.obolibrary.org/obo/MONDO_0016312 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/MONDO_0016312">
        <rdfs:label>5-fluorouracil poisoning</rdfs:label>
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        <ns3:IAO_0000233 rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/monarch-initiative/mondo/issues/5652</ns3:IAO_0000233>
        <ns4:curated_content_resource rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://www.malacards.org/card/5_fluorouracil_poisoning</ns4:curated_content_resource>
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        <oboInOwl:hasDbXref>MESH:C531667</oboInOwl:hasDbXref>
        <oboInOwl:id>MONDO:0016312</oboInOwl:id>
        <ns3:IAO_0000115>5-fluorouracil (5-FU) poisoning is a rare intoxication caused by the prolonged, low-dose administration of 5-FU, which is the mainstay of both adjuvant and advanced-disease chemotherapy regimens in colon cancer. 5-FU poisoning is characterized by gastrointestinal (nausea, emesis, diarrhea, anorexia, stomatitis) and hematologic (myelosuppression) toxicities as well as mucositis, alopecia and, occasionally, palmar-plantar dysesthesia (more commonly known as hand-foot syndrome). Women have been reported to experience more 5-FU-related toxicity than men.</ns3:IAO_0000115>
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