immune system disorder anti-HLA hyperimmunization https://rarediseases.info.nih.gov/diseases/730/anti-hla-hyperimmunization Anti-HLA hyperimmunization is an increase in anti-HLA antigens mostly seen in chronic renal failure (CRF) patients that have undergone hemodialysis and polytransfusion. Orphanet:2194 GARD:0000730 UMLS:C4304034 MEDGEN:929703 MONDO:0016351