systemic sclerosis limited systemic sclerosis progressive systemic sclerosis sine scleroderma Scleroderma, sine SCTID:128461001 GARD:0009749 systemic sclerosis without skin involvement MEDGEN:220934 UMLS:C1290138 icd11.foundation:187455179 Orphanet:220407 MONDO:0016359 NCIT:C116789 systemic sclerosis sine scleroderma Limited systemic sclerosis (lSSc) (or SSc sine scleroderma) is a subset of systemic sclerosis (SSc) characterized by organ involvement in the absence of fibrosis of the skin. SSC without skin involvement