neurodegenerative disease Marchiafava-Bignami disease https://rarediseases.info.nih.gov/diseases/6971/marchiafava-bignami-disease https://www.malacards.org/card/marchiafava_bignami_disease_2 MONDO:0016370 Marchiafava Bignami disease Marchiafava Bignami disease is defined by characteristic demyelination of the corpus callosum (erosion of the protective covering of nerve fibers joining the 2 hemispheres of the brain). The disease seems to most often affect severe and chronic alcoholics in their middle or late adult life. Early symptoms may include depression, paranoia, psychosis, or dementia. Seizures are common, and hemiparesis, aphasia, abnormal movements, and ataxia may sometimesprogress to coma and/or death. The cause of Marchiafava Bignami disease, including the potential role of nutritional deficiency, remains unknown. Improvement and recovery of some individuals has been reported. Treatment focuses on nutritional support and rehabilitation from alcoholism. SCTID:386766007 MedDRA:10026828 Orphanet:221074 MESH:D054319 EFO:1001809 MEDGEN:65955 chronic Marchiafava-Bignami syndrome MBD icd11.foundation:1694687314 ICD9:341.8 GARD:0006971 acute Marchiafava-Bignami disease UMLS:C0238265