syndromic disease hereditary disease heart-hand syndrome https://github.com/monarch-initiative/mondo/issues/6751 https://github.com/monarch-initiative/mondo/issues/6877 UMLS:C5848054 MONDO:0016432 atriodigital dysplasia GARD:0020573 MEDGEN:1853290 Orphanet:228184 Heart-hand syndrome refers to a group of congenital disorders characterized by malformations of the upper limbs and heart. To date, heart-hand syndrome comprises the following rare syndromes; Holt-Oram syndrome; heart-hand syndrome type 2; heart-hand syndrome type 3; heart hand syndrome, Slovenian type, brachydactyly-long thumb; and patent ductus arteriosus-bicuspid aortic valve - hand anomalies. dysostosis congenital limb malformation