realized in response to stimulus isotretinoin syndromic disease isotretinoin-like syndrome isotretinoin syndrome https://www.malacards.org/card/isotretinoin_syndrome Orphanet:2305 Accutane fetal effects of foetal isotretinoin syndrome fetal isotretinoin syndrome MEDGEN:419683 Accutane-exposed pregnancies Isotretinoin foetal effects of Fetal Retinoid Syndrome NCIT:C98929 Isotretinoin embryopathy foetal retinoid syndrome fetal retinoid syndrome Isotretinoin (RoAccutane) embryopathy MONDO:0016467 Isotretinoin fetal effects of retinoic acid embryopathy SCTID:36871005 MESH:C535670 Accutane foetal effects of Retinoids embryopathy Acutane embryopathy Isotretinoin teratogen syndrome UMLS:C2930972 Isotretinoin embryopathy is an association of malformations caused by the teratogenic effect of isotretinoin, an oral synthetic vitamin A derivative, which is used to treat severe recalcitrant cystic acne. Exposure to isotretinoin during the first trimester of pregnancy has been associated with an increased risk of spontaneous abortions and severe birth defects including serious craniofacial (microcephaly, asymmetric crying facies, microphthalmia, developmental abnormalities of the external ear, ocular hypertelorism), cardio vascular (conotruncal heart defects, aortic arch abnormalities), and central nervous system (hydrocephalus, microcephaly, lissencephaly, Dandy-Walker malformation, cognitive deficit) anomalies and thymic aplasia. Isoretinoin is contraindicated during pregnancy. NORD:1140 toxic or drug-related embryofetopathy