disease has basis in disruption of disease caused by disruption of disease has feature ectoderm and mesoderm interaction ectodermal placode development Hypohidrosis hypohidrotic ectodermal dysplasia https://github.com/monarch-initiative/mondo/issues/4104 anhidrotic ectodermal dysplasia 1 MONDO:0016535 A genetic disorder of ectoderm development characterized by malformation of ectodermal structures such as skin, hair, teeth and sweat glands. It comprises three clinically almost indistinguishable subtypes with impaired sweating as the key symptom: Christ-Siemens-Touraine (CST) syndrome (X-linked), autosomal recessive (AR), and autosomal dominant (AD) HED, as well as a fourth rare subtype with immunodeficiency as the key symptom (HED with immunodeficiency). anhidrotic ectodermal dysplasia 3 MEDGEN:1853123 Orphanet:238468 EDA HP:0007607 NCIT:C84562 NANDO:2201005 UMLS:C5848103 NORD:1272 DOID:14793 DOID classifies this as a subtype of Clouston disease but this seems to be a confusion re hidrotic vs hypohidrotic ectodermal dysplasia 1, Anhydrotic ectodermal dysplasia, hypohidrotic CST syndrome GARD:0000076 ectodermal dysplasia anhidrotic anhidrotic ectodermal dysplasia HED icd11.foundation:673167184 hypohidrotic X-linked ectodermal dysplasia ectodermal dysplasia syndrome disorder of development or morphogenesis